This research group studies the recruitment of histone modifying complexes to transcriptionally active genes in yeast.
Chromatin is a nucleoprotein structure, consisting of DNA, histones, and non-histone proteins, which packages DNA in the eukaryotic nucleus. Our research focuses on multi-protein complexes which post-translationally modify histones. We are interested in determining how these complexes are targeted to specific regions of the genome, and the functional consequences of this targeting. We use the budding yeast, Saccharomyces cerevisiae , as a model system due to its well-defined genetic system and the fact that there are a large number of eukaryotic genes that have been evolutionarily conserved between yeast and mammals.