Lefebvre Lab Publications

2016

Branco, M.R., King, M., Bogutz, A.B., Lefebvre, L., Cook, S.J., Dean, W., Hemberger, M., Reik, W.
Maternal DNA methylation regulates early trophoblast development.
Developmental Cell 36(2):152-163 (2016).

2015

Angela D. Kelsey, Christine Yang, Danny C.Y. Leung, Jakub Minks, Thomas Dixon-McDougall, Sarah E.L. Baldry, Aaron B. Bogutz, Louis Lefebvre, Carolyn J. Brown.
Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST. Genome Biology 16:208 (2015).

2014

Sheng Liu, Julie Brind’Amour, Mohammad M Karimi, Kenjiro Shirane, Aaron Bogutz, Louis Lefebvre, Hiroyuki Sasaki, Yoichi Shinkai, and Matthew C Lorincz.

Setdb1 is required for germ line development and silencing of H3K9me3 marked endogenous retroviruses in primordial germ cells.

Genes & Development 28: 2041-2055 (2014).

2013

Jacob, K.J., Robinson W.R., and Lefebvre, L.
Beckwith-Wiedemann and Silver-Russell syndromes: opposite developmental imbalances in imprinted regulators of placental function and embryonic growth.
 Clinical Genetics (2013).

2012

Lefebvre, L. The placental imprintome and imprinted gene function in the trophoblast glycogen cell lineage. Guest Symposium on Trophoblast Development, Reproductive BioMedicine Online 25(1):44-57 (2012).

Lefebvre, L. Engineering of large deletions and duplications in vivo.
Chapter in Genomic Imprinting: Methods and ProtocolsMethods in Molecular Biology, vol. 925, Engel, Nora  (Ed.), Humana Press, Springer (2012).

MacIsaac, J.L., Bogutz, A.B., Morrissy, A.S., and Lefebvre, L.
Tissue-specific alternative polyadenylation at the imprinted gene Mest regulates allelic usage at Copg2. Nuclei Acids Research 40(4):1523-1535 (2012).

2011

Jones, J.M., Bogutz, A.B., and Lefebvre, L.
An extended domain of Kcnq1ot1 silencing revealed by an imprinted fluorescent reporter.
Molecular and Cellular Biology 31(14):2827-2837 (2011).

Oh-McGinnis, R., Bogutz, A.B., and Lefebvre, L.
Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction. Developmental Biology 351(2):277-86 (2011).

John, R. and Lefebvre, L. Developmental regulation of somatic imprints. Differentiation 81:270-280 (2011).

2010

Oh-McGinnis, R., Jones, M.J. and Lefebvre, L. Applications of the site-specific recombinase Cre to the study of genomic imprinting. Briefings in Functional Genomics 9(4):281-293 (2010).

Oh-McGinnis, R., Bogutz, A.B., Lee, Y.L., Higgins, M.J., and Lefebvre, L. Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Developmental Biology 10:50 (2010).

2009

Jones, M. and Lefebvre, L. An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages. Developmental Biology 336:42-52 (2009).

Lefebvre, L., Mar, L., Bogutz, A., Oh-McGinnis, R., Mandegar, M.A., Paderova, J., Gertsenstein, M., Squire, J.A., and Nagy, A.The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region. Human Molecular Genetics 18(22):4255-4267 (2009).

Yuen, R.K.C., Avila, L., Penaherrera, M.S., von Dadelszen, P., Lefebvre, L., Kobor, M.S., and Robinson, W.P. Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes. PLoS ONE 4(10):e7389 (2009).

2008

Oh, R., Ho, R., Mar, L., Gertsenstein, M., Paderova, J., Hsien, J., Squire, J.A., Higgins, M.J., Nagy, A., and Lefebvre, L. Epigenetic and phenotypic consequences of a truncation engineered within the imprinted domain on distal mouse chromosome 7. Molecular and Cellular Biology 28(3):1092-1103 (2008).

2007

The International Mouse Knockout Consortium. A Mouse for All Reasons. Cell 128:9-13 (2007).

2006

Kaiser-Rogers, K.A. , McFadden, D.E., Livasy, C.A., Dansereau, J., Jiang, R., Knops, J.F., Lefebvre, L., Rao, K.W., Robinson, W.P. Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia. J. Med. Genet. 43(2):187-92 (2006).

2004

Shi, W., Lefebvre, L., Yu, Y., Otto, S., Krella, A., Orth, A., and Fundele, R. Loss-of-imprinting of Peg1 in mouse interspecific hybrids is correlated with altered growth. genesis 39:65-72 (2004).

2001

Lefebvre, L., Dionne, N., Karaskova, J., Squire, J.A., and Nagy, A. Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity. Nature Genetics 27(3):257-258 (2001).

1990-1999

Viville, S. et Lefebvre, L. Empreinte génomique, comportement maternel et conflit d’intérêt reproductif. médecine/sciences 15:528-534 (1999).

Lefebvre, L., Viville, S., Barton, S.C., Ishino, F., Keverne, E.B., and Surani, M.A. Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nature Genetics 20(2):163-169 (1998).

Tada, M., Tada, T., Lefebvre, L., Barton, S.C., and Surani, M.A. Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J. 16(21):6510-6520 (1997).

Lefebvre, L., Viville, S., Barton, S.C., Ishino, F., and Surani, M.A. Genomic structure and parent-of-origin-specific methylation of Peg1. Hum. Mol. Genet. 6(11):1907-1915 (1997).

Lefebvre, L. and Smith, M. Mutational and Functional Analysis of Dominant SPT2 (SIN1) Suppressor Alleles in Saccharomyces cerevisiae. Mol. Cell. Biol. 13(9):5393-5407 (1993).

Mehta, K.D., Leung, D., Lefebvre, L., and Smith, M. The ANBl Locus of Saccharomyces cerevisiae Encodes the Protein Synthesis Initiation Factor eIF-4D. Jour. Biol. Chem. 265(15):8802-8807 (1990).

 

 

Selected publications

 

 

 

R Oh-McGinnis, MJ Jones, and L Lefebvre. Applications of the site-specific recombinase Cre to the study of genomic imprinting. Briefings in Functional Genomics. Advance Access published on July 2, 2010. doi:10.1093/bfgp/elq017 (2010).

 


Oh-McGinnis, R., Bogutz, A.B., Lee, Y.L., Higgins, M.J., and Lefebvre, L. Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Developmental Biology 10:50 (2010).

 

 


Jones, M. and Lefebvre, L. An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages. Developmental Biology 336:42-52 (2009).


Lefebvre, L., Mar, L., Bogutz, A., Oh-McGinnis, R., Mandegar, M.A., Paderova, J., Gertsenstein, M., Squire, J.A., and Nagy, A. The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region. Human Molecular Genetics 18(22):4255-4267 (2009).


Yuen, R.K.C., Avila, L., Penaherrera, M.S., von Dadelszen, P., Lefebvre, L., Kobor, M.S., and Robinson, W.P. Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes. PLoS ONE 4(10):e7389 (2009).

 


Oh, R., Ho, R., Mar, L., Gertsenstein, M., Paderova, J., Hsien, J., Squire, J.A., Higgins, M.J., Nagy, A., and Lefebvre, L. Epigenetic and phenotypic consequences of a truncation engineered within the imprinted domain on distal mouse chromosome 7. Molecular and Cellular Biology 28(3):1092-1103 (2008).

 


The International Mouse Knockout Consortium. A mouse for all reasons. Cell 128:9-13 (2007).

Selected publications

R Oh-McGinnis, MJ Jones, and L Lefebvre. Applications of the site-specific recombinase Cre to the study of genomic imprinting. Briefings in Functional Genomics. Advance Access published on July 2, 2010. doi:10.1093/bfgp/elq017 (2010).

Oh-McGinnis, R., Bogutz, A.B., Lee, Y.L., Higgins, M.J., and Lefebvre, L. Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Developmental Biology 10:50 (2010).

Jones, M. and Lefebvre, L. An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages. Developmental Biology 336:42-52 (2009).

Lefebvre, L., Mar, L., Bogutz, A., Oh-McGinnis, R., Mandegar, M.A., Paderova, J., Gertsenstein, M., Squire, J.A., and Nagy, A. The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region. Human Molecular Genetics 18(22):4255-4267 (2009).

Yuen, R.K.C., Avila, L., Penaherrera, M.S., von Dadelszen, P., Lefebvre, L., Kobor, M.S., and Robinson, W.P. Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes. PLoS ONE 4(10):e7389 (2009).

Oh, R., Ho, R., Mar, L., Gertsenstein, M., Paderova, J., Hsien, J., Squire, J.A., Higgins, M.J., Nagy, A., and Lefebvre, L. Epigenetic and phenotypic consequences of a truncation engineered within the imprinted domain on distal mouse chromosome 7. Molecular and Cellular Biology 28(3):1092-1103 (2008).

The International Mouse Knockout Consortium. A mouse for all reasons. Cell 128:9-13 (2007).

Kaiser-Rogers, K.A. , McFadden, D.E., Livasy, C.A., Dansereau, J., Jiang, R., Knops, J.F., Lefebvre, L., Rao, K.W., Robinson, W.P. Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia. J. Med. Genet. 43(2):187-92. (2006).

Shi, W., Lefebvre, L., Yu, Y., Otto, S., Krella, A., Orth, A., and Fundele, R. Loss-of-imprinting of Peg1 in mouse interspecific hybrids is correlated with altered growth. genesis 39:65-72. (2004).

Lefebvre, L., Dionne, N., Karaskova, J., Squire, J.A., and Nagy, A. Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity. Nature Genetics 27(3):257-258. (2001).

Lefebvre, L., Viville, S., Barton, S.C., Ishino, F., Keverne, E.B., and Surani, M.A. Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nature Genetics 20(2):163-169. (1998).

 


Kaiser-Rogers, K.A. , McFadden, D.E., Livasy, C.A., Dansereau, J., Jiang, R., Knops, J.F., Lefebvre, L., Rao, K.W., Robinson, W.P. Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia. J. Med. Genet. 43(2):187-92. (2006).

 


Shi, W., Lefebvre, L., Yu, Y.,Otto, S., Krella, A., Orth, A., and Fundele, R.Loss-of-imprinting of Peg1 in mouse interspecific hybrids is correlated with altered growth.genesis 39:65-72. (2004).

 

 


Lefebvre, L., Dionne, N., Karaskova, J., Squire, J.A., and Nagy, A.Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity.Nature Genetics 27(3):257-258. (2001).

 


Lefebvre, L., Viville, S., Barton, S.C., Ishino, F., Keverne, E.B., and Surani, M.A.Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest.Nature Genetics 20(2):163-169. (1998).

a place of mind, The University of British Columbia

Molecular Epigenetics
2350 Health Sciences Mall,
Vancouver, BC, V6T 1Z3, Canada

Emergency Procedures | Accessibility | Contact UBC  | © Copyright The University of British Columbia