Sherry Fang, Kai-Wei Chang and Louis Lefebvre.
Roles of endogenous retroviral elements in the establishment and maintenance of imprinted gene expression.
Front. Cell Dev. Biol., Sec. Developmental Epigenetics, Volume 12 (2024)
Vahid Akbari, Vincent C.T. Hanlon, Kieran O’Neill, Louis Lefebvre, Kasmintan A. Schrader, Peter M. Lansdorp, Steven J.M. Jones.
Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq.
Cell Genomics 3(1):100233 (2023)
R.M. John, L. Lefebvre & M.A. Surani.
Genomic Imprinting: A Paradigm for Epigenetics of Human Diseases
In Karin B. Michels (Ed.). Epigenetic Epidemiology, pp. 171-212
Springer (2022)
Takamasa Ito, Musashi Kubiura-Ichimaru, Yuri Murakami, Aaron B. Bogutz, Louis Lefebvre, Isao Suetake, Shoji Tajima, and Masako Tada.
DNMT1 regulates de novo DNA methylation by DNMT3 both in an enzymatic activity-dependent and independent manner.
PLoS One 17(1): e0262277 (2022)
Musashi Kubiura-Ichimaru, Takamasa Ito, Louis Lefebvre, and Masako Tada.
Cyclic DNA remethylation following active demethylation at euchromatic regions in mouse embryonic stem cells.
Chromosome Research 29: 145-157 (2021)
Amanda Haage, Kelsey Wagner, Wenjun Deng, Bhavya Venkatesh, Caitlin Mitchell, Katharine Goodwin, Aaron Bogutz, Louis Lefebvre, Catherine D. Van Raamsdonk, Guy Tanentzapf.
Precise coordination of cell-ECM adhesion is essential for efficient melanoblast migration during development.
Development 147 (14): dev184234 (2020)
Aaron B. Bogutz, Julie Brind’Amour, Hisato Kobayashi, Kristoffer N. Jensen, Kazuhiko Nakabayashi, Hiroo Imai, Matthew C. Lorincz, and Louis Lefebvre.
Evolution of imprinting via lineage-specific insertion of retroviral promoters.
Nature Communications 10, Article number: 5674 (2019)
Xu, Q., Xiang, Y., Wang, Q., Wang, L., Brind’Amour, J., Bogutz, A. B., Zhang, Y., Zhang, B., Yu, G., Xia, W., Du, Z., Huang, C., Ma, J., Zheng, H., Li, Y., Liu, C., Walker, C. L., Jonasch, E., Lefebvre, L., Wu, M., Lorincz, M. C., Li, W., Li, L. & Xie, W.
SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development.
Nature Genetics 51(5):844-856 (2019)
Haage, A., Goodwin, K., Whitewood,A. Bogutz, A.B., Lefebvre, L., Plotnikov, S., Goult, B.T., Tanentzapf, G.
Talin autoinhibition regulates cell-ECM adhesion dynamics and wound healing in vivo.
Cell Reports 25:2401-2416 (2018)
Tunster, S.J., Van de Pette, M., Creeth, H.D.J., Lefebvre, L. and John, R.M.
Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann Syndrome.
Disease Models & Mechanisms 11:dmm035832 (2018)
Brind’Amour, J., Kobayashi, H., Albert, J.R., Shirane, K., Sakashita, A., Kamio, A., Bogutz, A.B., Koike, T., Karimi, M.M., Lefebvre, L., Kono, T., and Lorincz, M.C.
LTR retrotransposons transcribed in oocytes drive species-specific, heritable changes in DNA methylation.
Nature Communications 9, Article number: 3331(2018)
Bogutz, A.B., Oh-McGinnis, R., Jacob, K.J., Ho-Lau, R., Gu, T., Gertsenstein, M., Nagy, A., Lefebvre, L.
Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage.
PLoS Genetics 14, e1007587 (2018)
Branco, M.R., King, M., Bogutz, A.B., Lefebvre, L., Cook, S.J., Dean, W., Hemberger, M., Reik, W.
Maternal DNA methylation regulates early trophoblast development.
Developmental Cell 36(2):152-163 (2016)
Angela D. Kelsey, Christine Yang, Danny C.Y. Leung, Jakub Minks, Thomas Dixon-McDougall, Sarah E.L. Baldry, Aaron B. Bogutz, Louis Lefebvre, Carolyn J. Brown. Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST. Genome Biology 16:208 (2015)
Sheng Liu, Julie Brind’Amour, Mohammad M Karimi, Kenjiro Shirane, Aaron Bogutz, Louis Lefebvre, Hiroyuki Sasaki, Yoichi Shinkai, and Matthew C Lorincz.
Setdb1 is required for germ line development and silencing of H3K9me3 marked endogenous retroviruses in primordial germ cells.
Genes & Development 28: 2041-2055 (2014)
Jacob, K.J., Robinson W.R., and Lefebvre, L.
Beckwith-Wiedemann and Silver-Russell syndromes: opposite developmental imbalances in imprinted regulators of placental function and embryonic growth.
Clinical Genetics 84(4):326-334 (2013)
Lefebvre, L. The placental imprintome and imprinted gene function in the trophoblast glycogen cell lineage. Guest Symposium on Trophoblast Development,
Reproductive BioMedicine Online 25(1):44-57 (2012)
Lefebvre, L. Engineering of large deletions and duplications in vivo.
Chapter in Genomic Imprinting: Methods and Protocols
Methods in Molecular Biology, vol. 925, Engel, Nora (Ed.), Humana Press, Springer (2012)
MacIsaac, J.L., Bogutz, A.B., Morrissy, A.S., and Lefebvre, L.
Tissue-specific alternative polyadenylation at the imprinted gene Mest regulates allelic usage at Copg2.
Nuclei Acids Research 40(4):1523-1535 (2012)
Jones, J.M., Bogutz, A.B., and Lefebvre, L.
An extended domain of Kcnq1ot1 silencing revealed by an imprinted fluorescent reporter.
Molecular and Cellular Biology 31(14):2827-2837 (2011)
Oh-McGinnis, R., Bogutz, A.B., and Lefebvre, L.
Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
Developmental Biology 351(2):277-86 (2011)
John, R. and Lefebvre, L. Developmental regulation of somatic imprints.
Differentiation 81:270-280 (2011)
Oh-McGinnis, R., Jones, M.J. and Lefebvre, L.
Applications of the site-specific recombinase Cre to the study of genomic imprinting.
Briefings in Functional Genomics 9(4):281-293 (2010)
Oh-McGinnis, R., Bogutz, A.B., Lee, Y.L., Higgins, M.J., and Lefebvre, L.
Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome.
BMC Developmental Biology 10:50 (2010)
Jones, M. and Lefebvre, L. An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages.
Developmental Biology 336:42-52 (2009)
Lefebvre, L., Mar, L., Bogutz, A., Oh-McGinnis, R., Mandegar, M.A., Paderova, J., Gertsenstein, M., Squire, J.A., and Nagy, A.
The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.
Human Molecular Genetics 18(22):4255-4267 (2009)
Yuen, R.K.C., Avila, L., Penaherrera, M.S., von Dadelszen, P., Lefebvre, L., Kobor, M.S., and Robinson, W.P.
Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes.
PLoS ONE 4(10):e7389 (2009)
Oh, R., Ho, R., Mar, L., Gertsenstein, M., Paderova, J., Hsien, J., Squire, J.A., Higgins, M.J., Nagy, A., and Lefebvre, L.
Epigenetic and phenotypic consequences of a truncation engineered within the imprinted domain on distal mouse chromosome 7.
Molecular and Cellular Biology 28(3):1092-1103 (2008)
Kaiser-Rogers, K.A. , McFadden, D.E., Livasy, C.A., Dansereau, J., Jiang, R., Knops, J.F., Lefebvre, L., Rao, K.W., Robinson, W.P. Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia.
J. Med. Genet. 43(2):187-92 (2006)
Shi, W., Lefebvre, L., Yu, Y., Otto, S., Krella, A., Orth, A., and Fundele, R.
Loss-of-imprinting of Peg1 in mouse interspecific hybrids is correlated with altered growth.
genesis 39:65-72 (2004)
Other Publications
Lefebvre, L., Dionne, N., Karaskova, J., Squire, J.A., and Nagy, A.
Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity.
Nature Genetics 27(3):257-258 (2001)
Viville, S. et Lefebvre, L. Empreinte génomique, comportement maternel et conflit d’intérêt reproductif.
médecine/sciences 15:528-534 (1999)
Lefebvre, L., Viville, S., Barton, S.C., Ishino, F., Keverne, E.B., and Surani, M.A.
Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest.
Nature Genetics 20(2):163-169 (1998)
Tada, M., Tada, T., Lefebvre, L., Barton, S.C., and Surani, M.A.
Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells.
EMBO J. 16(21):6510-6520 (1997)
Lefebvre, L., Viville, S., Barton, S.C., Ishino, F., and Surani, M.A.
Genomic structure and parent-of-origin-specific methylation of Peg1.
Hum. Mol. Genet. 6(11):1907-1915 (1997)
Lefebvre, L. and Smith, M.
Mutational and Functional Analysis of Dominant SPT2 (SIN1) Suppressor Alleles in Saccharomyces cerevisiae.
Mol. Cell. Biol. 13(9):5393-5407 (1993)
Mehta, K.D., Leung, D., Lefebvre, L., and Smith, M.
The ANBl Locus of Saccharomyces cerevisiae Encodes the Protein Synthesis Initiation Factor eIF-4D.
J. Biol. Chem. 265(15):8802-8807 (1990)
