This handout is designed to introduce and illustrate the research happening within the LSI Research Groups.
The Molecular Epigenetics Group (MEG) of the Life Sciences Institute at the University of British Columbia consists of 8 researchers from 3 departments (Biochemistry, Medical Genetics, and Zoology) with a common interest in epigenetic gene regulation.
Carolyn Brown’s laboratory studies the mechanism of human X chromosome inactivation – the process that equalizes the expression of X-linked genes between males and females.
Dr. Lorincz’s laboratory is focused on the interplay between transcription, DNA methylation and histone modifications in murine cells.
The research group of Louis Lefebvre studies the phenomenon of genomic imprinting, an epigenetic system guiding the monoallelic, parent-of-origin dependent expression of specific genes in mammals.
Our research focuses on multi-protein complexes which post-translationally modify histones.
Cancer cells and cells in developing embryos share two important characteristics: they rapidly proliferate and they are capable of migrating extensively.
Our laboratory studies how environmental signals affect transcriptional regulation in yeast using a combination of biochemical, molecular and genetic analysis.