Brown Lab:


X: A mosaic with XIST

X: A mosaic with XIST

Dr. Carolyn Brown

Lab Webpage


Carolyn Brown’s laboratory studies the mechanism of human X chromosome inactivation – the process that equalizes the expression of X-linked genes between males and females.

X chromosome inactivation occurs early during mammalian development to transcriptionally silence one of the pair of X chromosomes in females, thereby achieving dosage equivalence with males who have a single X chromosome and the sex-determining Y chromosome. Research in the lab is directed towards understanding both the mechanisms involved in the inactivation process and the clinical implications of X chromosome inactivation in females.

a place of mind, The University of British Columbia

Molecular Epigenetics
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Vancouver, BC, V6T 1Z3, Canada

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