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This handout is designed to introduce and illustrate the research happening within the LSI Research Groups.
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The Molecular Epigenetics Group (MEG) of the Life Sciences Institute at the University of British Columbia consists of 8 researchers from 3 departments (Biochemistry, Medical Genetics, and Zoology) with a common interest in epigenetic gene regulation.
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Carolyn Brown’s laboratory studies the mechanism of human X chromosome inactivation – the process that equalizes the expression of X-linked genes between males and females.
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Dr. Lorincz’s laboratory is focused on the interplay between transcription, DNA methylation and histone modifications in murine cells.
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The research group of Louis Lefebvre studies the phenomenon of genomic imprinting, an epigenetic system guiding the monoallelic, parent-of-origin dependent expression of specific genes in mammals.
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Our research focuses on multi-protein complexes which post-translationally modify histones.
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Cancer cells and cells in developing embryos share two important characteristics: they rapidly proliferate and they are capable of migrating extensively.
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Our laboratory studies how environmental signals affect transcriptional regulation in yeast using a combination of biochemical, molecular and genetic analysis.
